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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
50 Results for "
Trillium tschonoskii Maxim.
" in MedChemExpress (MCE) Product Catalog:
Products (50)
50 Results for " Trillium tschonoskii Maxim." in MCE Product Catalog:
8
8 Publications Verification
Cat. No.: HY-N0213
CAS No.: 18059-10-4
Synonyms: Verticinone; Raddeanine
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Flavonols Flavonoids Phenols Polyphenols Epimedium brevicornu Maxim. Plants Berberidaceae Disease Research Fields Cancer
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Cat. No.: HY-N0730
CAS No.: 14144-06-0
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Alkaloids other families Monophenols Phenols Plants Disease Research Fields Isoquinoline Alkaloids Cancer
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PSMA binder-1 is a ligand for PSMA and can be used to synthesize PSMA targeting molecule, such as Ac-PSMA-trillium .
Cat. No.: HY-N0121A
CAS No.: 13079-95-3
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Asarum forbesii Maxim. Other Diseases Lignans Phenylpropanoids Plants Disease Research Fields Aristolochiaceae
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Cat. No.: HY-158119A
CAS No.: 3036415-37-6
Synonyms: Felivotide mopaxetan
PSMA-trillium (Felivotide mopaxetan) is a PSMA-targeted molecule that contains a highly specific PSMA-binding motif, an albumin-binding domain optimized for tumor uptake and retention, and a Macropa chelator conjugated to the α-emitter 225Ac. PSMA-trillium binds to albumin to prolong plasma retention time and binds to PSMA via its specific motif. 225Ac-PSMA-Trillium exhibits dose-dependent inhibition of LNCaP tumor growth in mice. PSMA-trillium can be used in research related to prostate cancer and metastatic castration-resistant prostate cancer .
Lys(CO-C3-p-I-Ph)-OMe is a pharmacokinetic modifier (PK modifier) that can improve the PK properties of PSMA ligand molecules (such as Ac-PSMA-trillium). Lys(CO-C3-p-I-Ph)-OMe can increase the residence time of Ac-PSMA-trillium in plasma by increasing its binding capacity to albumin. Lys(CO-C3-p-I-Ph)-OMe also reduces salivary gland absorption of Ac-PSMA-trillium, potentially extending its half-life. Ac-PSMA-trillium is a suitable PSMA-targeting compound that has different biological applications after modification with different radioactive isotopes. If labeled with 111In, it can be used as DOTA chelating agent and imaging agent. Or labeled with 225Ac as a Macropa chelator for targeted radionuclide therapy (TRT) in the study of metastatic castration-resistant prostate cancer (mCRPC) .
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PSMA binder-2 is a ligand for PSMA and can be used to synthesize Ac-PSMA-trillium. Ac-PSMA-trillium is a suitable PSMA-targeting compound with improved PSMA binding properties and pharmacokinetic properties. PSMA ligands have different biological applications after being modified with different radioactive isotopes. If labeled with 111In, it can be used as DOTA chelating agent and imaging agent. Or labeled with 225Ac as a Macropa chelator for targeted radionuclide therapy (TRT) in the study of metastatic castration-resistant prostate cancer (mCRPC) .
Cat. No.: HY-N8598
CAS No.: 1159989-19-1
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Cat. No.: HY-N6672
CAS No.: 1359978-55-4
Category:
Alkaloids Caulophyllum robustum Maxim. Phenols Polyphenols Plants Berberidaceae Disease Research Fields Inflammation/Immunology
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Phenols Polyphenols Plants Camellia sinensis (L.) O. Ktze. Disease Research Fields Cancer Theaceae
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Cat. No.: HY-N5057
CAS No.: 136112-75-9
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Cardiovascular Disease Labiatae Terpenoids Samanea saman (Jacq.) Merr. Phenols Polyphenols Diterpenoids Plants Disease Research Fields
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Cat. No.: HY-N16566
CAS No.: 811471-19-9
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Cat. No.: HY-N0730R
CAS No.: 14144-06-0
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Cat. No.: HY-16958R
CAS No.: 72596-74-8
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Paris saponin VII (Standard) is the analytical standard of Paris saponin VII. This product is intended for research and analytical applications. Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia .
Cat. No.: HY-N3584R
CAS No.: 68124-04-9
Synonyms: Chonglou Saponin VII (Standard)
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Cat. No.: HY-N8708
CAS No.: 39765-50-9
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
